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lipids dphpc  (Croda International Plc)

 
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    Structured Review

    Croda International Plc lipids dphpc
    A ) Left , image of a voltage clamped primary cilia in the on-cilia configuration. The primary cilium of HEK (PKD1 Null :PKD2 Null ) cells transiently expressing PKD2 channels are illuminated by ARL13B-GFP under 475 nm laser excitation. Right , example single channel recordings from the cilia membrane activated by depolarizing voltage steps. Note, no open channel events were observed in cilia patch recordings from cells expressing D511V channels. B ) Left , example polycystin unitary single channel events recorded from cilia membranes. Right , corresponding histograms indicating the frequency of a variable simultaneous open channel events (O 1 -O 3 ) and closure (C). Note, no channel openings are detected from cilia recordings from cells expressing D511V channels. C ) Column plots indicating the frequency of the maximum simultaneous open channel events from cilia patches. Number of events are indicated in parenthesis. D ) Image of a voltage clamped giant unilaminear vesicals (GUVs) reconstituted with cell free expressed PKD2-GFP protein. E ) Top , example WT PKD2-GFP unitary single channel events recorded (HP = 40mV) from GUVs composed of either 1,2-diphytanoyl-sn-glycero-phosphocholine (DPhPC) or 95% DPhPC and 5% <t>cholesterol</t> (Bovine). Bottom , lack of single channel events from D511V channels reconstituted in GUVs. F ) Column plots indicating the frequency of the maximum simultaneous open channel events from GUVs patches. Number of recordings indicated above for each column.
    Lipids Dphpc, supplied by Croda International Plc, used in various techniques. Bioz Stars score: 99/100, based on 7905 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Images

    1) Product Images from "PKD2 structural destabilization drives primary cilia degeneration and ADPKD pathogenicity"

    Article Title: PKD2 structural destabilization drives primary cilia degeneration and ADPKD pathogenicity

    Journal: bioRxiv

    doi: 10.64898/2026.06.24.734313

    A ) Left , image of a voltage clamped primary cilia in the on-cilia configuration. The primary cilium of HEK (PKD1 Null :PKD2 Null ) cells transiently expressing PKD2 channels are illuminated by ARL13B-GFP under 475 nm laser excitation. Right , example single channel recordings from the cilia membrane activated by depolarizing voltage steps. Note, no open channel events were observed in cilia patch recordings from cells expressing D511V channels. B ) Left , example polycystin unitary single channel events recorded from cilia membranes. Right , corresponding histograms indicating the frequency of a variable simultaneous open channel events (O 1 -O 3 ) and closure (C). Note, no channel openings are detected from cilia recordings from cells expressing D511V channels. C ) Column plots indicating the frequency of the maximum simultaneous open channel events from cilia patches. Number of events are indicated in parenthesis. D ) Image of a voltage clamped giant unilaminear vesicals (GUVs) reconstituted with cell free expressed PKD2-GFP protein. E ) Top , example WT PKD2-GFP unitary single channel events recorded (HP = 40mV) from GUVs composed of either 1,2-diphytanoyl-sn-glycero-phosphocholine (DPhPC) or 95% DPhPC and 5% cholesterol (Bovine). Bottom , lack of single channel events from D511V channels reconstituted in GUVs. F ) Column plots indicating the frequency of the maximum simultaneous open channel events from GUVs patches. Number of recordings indicated above for each column.
    Figure Legend Snippet: A ) Left , image of a voltage clamped primary cilia in the on-cilia configuration. The primary cilium of HEK (PKD1 Null :PKD2 Null ) cells transiently expressing PKD2 channels are illuminated by ARL13B-GFP under 475 nm laser excitation. Right , example single channel recordings from the cilia membrane activated by depolarizing voltage steps. Note, no open channel events were observed in cilia patch recordings from cells expressing D511V channels. B ) Left , example polycystin unitary single channel events recorded from cilia membranes. Right , corresponding histograms indicating the frequency of a variable simultaneous open channel events (O 1 -O 3 ) and closure (C). Note, no channel openings are detected from cilia recordings from cells expressing D511V channels. C ) Column plots indicating the frequency of the maximum simultaneous open channel events from cilia patches. Number of events are indicated in parenthesis. D ) Image of a voltage clamped giant unilaminear vesicals (GUVs) reconstituted with cell free expressed PKD2-GFP protein. E ) Top , example WT PKD2-GFP unitary single channel events recorded (HP = 40mV) from GUVs composed of either 1,2-diphytanoyl-sn-glycero-phosphocholine (DPhPC) or 95% DPhPC and 5% cholesterol (Bovine). Bottom , lack of single channel events from D511V channels reconstituted in GUVs. F ) Column plots indicating the frequency of the maximum simultaneous open channel events from GUVs patches. Number of recordings indicated above for each column.

    Techniques Used: Expressing, Membrane

    Related Articles

    other:

    Article Title: Resolving sulfation PTMs on a plant peptide hormone using nanopore sequencing
    Article Snippet: DPhPC lipids purchased from Avanti Polar Lipids (SKU: 850356C).

    Article Title: Resolving Sulfation Posttranslational Modifications on a Peptide Hormone using Nanopores.
    Article Snippet: Nanopore experiments on DNApeptide conjugate molecules were performed as described in previous studies.15,26 DPhPC lipids were purchased from Avanti Polar Lipids (SKU: 850356C).



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    A ) Left , image of a voltage clamped primary cilia in the on-cilia configuration. The primary cilium of HEK (PKD1 Null :PKD2 Null ) cells transiently expressing PKD2 channels are illuminated by ARL13B-GFP under 475 nm laser excitation. Right , example single channel recordings from the cilia membrane activated by depolarizing voltage steps. Note, no open channel events were observed in cilia patch recordings from cells expressing D511V channels. B ) Left , example polycystin unitary single channel events recorded from cilia membranes. Right , corresponding histograms indicating the frequency of a variable simultaneous open channel events (O 1 -O 3 ) and closure (C). Note, no channel openings are detected from cilia recordings from cells expressing D511V channels. C ) Column plots indicating the frequency of the maximum simultaneous open channel events from cilia patches. Number of events are indicated in parenthesis. D ) Image of a voltage clamped giant unilaminear vesicals (GUVs) reconstituted with cell free expressed PKD2-GFP protein. E ) Top , example WT PKD2-GFP unitary single channel events recorded (HP = 40mV) from GUVs composed of either 1,2-diphytanoyl-sn-glycero-phosphocholine (DPhPC) or 95% DPhPC and 5% <t>cholesterol</t> (Bovine). Bottom , lack of single channel events from D511V channels reconstituted in GUVs. F ) Column plots indicating the frequency of the maximum simultaneous open channel events from GUVs patches. Number of recordings indicated above for each column.
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    A ) Left , image of a voltage clamped primary cilia in the on-cilia configuration. The primary cilium of HEK (PKD1 Null :PKD2 Null ) cells transiently expressing PKD2 channels are illuminated by ARL13B-GFP under 475 nm laser excitation. Right , example single channel recordings from the cilia membrane activated by depolarizing voltage steps. Note, no open channel events were observed in cilia patch recordings from cells expressing D511V channels. B ) Left , example polycystin unitary single channel events recorded from cilia membranes. Right , corresponding histograms indicating the frequency of a variable simultaneous open channel events (O 1 -O 3 ) and closure (C). Note, no channel openings are detected from cilia recordings from cells expressing D511V channels. C ) Column plots indicating the frequency of the maximum simultaneous open channel events from cilia patches. Number of events are indicated in parenthesis. D ) Image of a voltage clamped giant unilaminear vesicals (GUVs) reconstituted with cell free expressed PKD2-GFP protein. E ) Top , example WT PKD2-GFP unitary single channel events recorded (HP = 40mV) from GUVs composed of either 1,2-diphytanoyl-sn-glycero-phosphocholine (DPhPC) or 95% DPhPC and 5% <t>cholesterol</t> (Bovine). Bottom , lack of single channel events from D511V channels reconstituted in GUVs. F ) Column plots indicating the frequency of the maximum simultaneous open channel events from GUVs patches. Number of recordings indicated above for each column.
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    A ) Left , image of a voltage clamped primary cilia in the on-cilia configuration. The primary cilium of HEK (PKD1 Null :PKD2 Null ) cells transiently expressing PKD2 channels are illuminated by ARL13B-GFP under 475 nm laser excitation. Right , example single channel recordings from the cilia membrane activated by depolarizing voltage steps. Note, no open channel events were observed in cilia patch recordings from cells expressing D511V channels. B ) Left , example polycystin unitary single channel events recorded from cilia membranes. Right , corresponding histograms indicating the frequency of a variable simultaneous open channel events (O 1 -O 3 ) and closure (C). Note, no channel openings are detected from cilia recordings from cells expressing D511V channels. C ) Column plots indicating the frequency of the maximum simultaneous open channel events from cilia patches. Number of events are indicated in parenthesis. D ) Image of a voltage clamped giant unilaminear vesicals (GUVs) reconstituted with cell free expressed PKD2-GFP protein. E ) Top , example WT PKD2-GFP unitary single channel events recorded (HP = 40mV) from GUVs composed of either 1,2-diphytanoyl-sn-glycero-phosphocholine (DPhPC) or 95% DPhPC and 5% <t>cholesterol</t> (Bovine). Bottom , lack of single channel events from D511V channels reconstituted in GUVs. F ) Column plots indicating the frequency of the maximum simultaneous open channel events from GUVs patches. Number of recordings indicated above for each column.
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    A ) Left , image of a voltage clamped primary cilia in the on-cilia configuration. The primary cilium of HEK (PKD1 Null :PKD2 Null ) cells transiently expressing PKD2 channels are illuminated by ARL13B-GFP under 475 nm laser excitation. Right , example single channel recordings from the cilia membrane activated by depolarizing voltage steps. Note, no open channel events were observed in cilia patch recordings from cells expressing D511V channels. B ) Left , example polycystin unitary single channel events recorded from cilia membranes. Right , corresponding histograms indicating the frequency of a variable simultaneous open channel events (O 1 -O 3 ) and closure (C). Note, no channel openings are detected from cilia recordings from cells expressing D511V channels. C ) Column plots indicating the frequency of the maximum simultaneous open channel events from cilia patches. Number of events are indicated in parenthesis. D ) Image of a voltage clamped giant unilaminear vesicals (GUVs) reconstituted with cell free expressed PKD2-GFP protein. E ) Top , example WT PKD2-GFP unitary single channel events recorded (HP = 40mV) from GUVs composed of either 1,2-diphytanoyl-sn-glycero-phosphocholine (DPhPC) or 95% DPhPC and 5% <t>cholesterol</t> (Bovine). Bottom , lack of single channel events from D511V channels reconstituted in GUVs. F ) Column plots indicating the frequency of the maximum simultaneous open channel events from GUVs patches. Number of recordings indicated above for each column.
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    A ) Left , image of a voltage clamped primary cilia in the on-cilia configuration. The primary cilium of HEK (PKD1 Null :PKD2 Null ) cells transiently expressing PKD2 channels are illuminated by ARL13B-GFP under 475 nm laser excitation. Right , example single channel recordings from the cilia membrane activated by depolarizing voltage steps. Note, no open channel events were observed in cilia patch recordings from cells expressing D511V channels. B ) Left , example polycystin unitary single channel events recorded from cilia membranes. Right , corresponding histograms indicating the frequency of a variable simultaneous open channel events (O 1 -O 3 ) and closure (C). Note, no channel openings are detected from cilia recordings from cells expressing D511V channels. C ) Column plots indicating the frequency of the maximum simultaneous open channel events from cilia patches. Number of events are indicated in parenthesis. D ) Image of a voltage clamped giant unilaminear vesicals (GUVs) reconstituted with cell free expressed PKD2-GFP protein. E ) Top , example WT PKD2-GFP unitary single channel events recorded (HP = 40mV) from GUVs composed of either 1,2-diphytanoyl-sn-glycero-phosphocholine (DPhPC) or 95% DPhPC and 5% <t>cholesterol</t> (Bovine). Bottom , lack of single channel events from D511V channels reconstituted in GUVs. F ) Column plots indicating the frequency of the maximum simultaneous open channel events from GUVs patches. Number of recordings indicated above for each column.
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    A ) Left , image of a voltage clamped primary cilia in the on-cilia configuration. The primary cilium of HEK (PKD1 Null :PKD2 Null ) cells transiently expressing PKD2 channels are illuminated by ARL13B-GFP under 475 nm laser excitation. Right , example single channel recordings from the cilia membrane activated by depolarizing voltage steps. Note, no open channel events were observed in cilia patch recordings from cells expressing D511V channels. B ) Left , example polycystin unitary single channel events recorded from cilia membranes. Right , corresponding histograms indicating the frequency of a variable simultaneous open channel events (O 1 -O 3 ) and closure (C). Note, no channel openings are detected from cilia recordings from cells expressing D511V channels. C ) Column plots indicating the frequency of the maximum simultaneous open channel events from cilia patches. Number of events are indicated in parenthesis. D ) Image of a voltage clamped giant unilaminear vesicals (GUVs) reconstituted with cell free expressed PKD2-GFP protein. E ) Top , example WT PKD2-GFP unitary single channel events recorded (HP = 40mV) from GUVs composed of either 1,2-diphytanoyl-sn-glycero-phosphocholine (DPhPC) or 95% DPhPC and 5% <t>cholesterol</t> (Bovine). Bottom , lack of single channel events from D511V channels reconstituted in GUVs. F ) Column plots indicating the frequency of the maximum simultaneous open channel events from GUVs patches. Number of recordings indicated above for each column.
    Diphytanoyl Sn Glycero 3 Phosphocholine Dphpc Lipid, supplied by Croda International Plc, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Image Search Results


    A ) Left , image of a voltage clamped primary cilia in the on-cilia configuration. The primary cilium of HEK (PKD1 Null :PKD2 Null ) cells transiently expressing PKD2 channels are illuminated by ARL13B-GFP under 475 nm laser excitation. Right , example single channel recordings from the cilia membrane activated by depolarizing voltage steps. Note, no open channel events were observed in cilia patch recordings from cells expressing D511V channels. B ) Left , example polycystin unitary single channel events recorded from cilia membranes. Right , corresponding histograms indicating the frequency of a variable simultaneous open channel events (O 1 -O 3 ) and closure (C). Note, no channel openings are detected from cilia recordings from cells expressing D511V channels. C ) Column plots indicating the frequency of the maximum simultaneous open channel events from cilia patches. Number of events are indicated in parenthesis. D ) Image of a voltage clamped giant unilaminear vesicals (GUVs) reconstituted with cell free expressed PKD2-GFP protein. E ) Top , example WT PKD2-GFP unitary single channel events recorded (HP = 40mV) from GUVs composed of either 1,2-diphytanoyl-sn-glycero-phosphocholine (DPhPC) or 95% DPhPC and 5% cholesterol (Bovine). Bottom , lack of single channel events from D511V channels reconstituted in GUVs. F ) Column plots indicating the frequency of the maximum simultaneous open channel events from GUVs patches. Number of recordings indicated above for each column.

    Journal: bioRxiv

    Article Title: PKD2 structural destabilization drives primary cilia degeneration and ADPKD pathogenicity

    doi: 10.64898/2026.06.24.734313

    Figure Lengend Snippet: A ) Left , image of a voltage clamped primary cilia in the on-cilia configuration. The primary cilium of HEK (PKD1 Null :PKD2 Null ) cells transiently expressing PKD2 channels are illuminated by ARL13B-GFP under 475 nm laser excitation. Right , example single channel recordings from the cilia membrane activated by depolarizing voltage steps. Note, no open channel events were observed in cilia patch recordings from cells expressing D511V channels. B ) Left , example polycystin unitary single channel events recorded from cilia membranes. Right , corresponding histograms indicating the frequency of a variable simultaneous open channel events (O 1 -O 3 ) and closure (C). Note, no channel openings are detected from cilia recordings from cells expressing D511V channels. C ) Column plots indicating the frequency of the maximum simultaneous open channel events from cilia patches. Number of events are indicated in parenthesis. D ) Image of a voltage clamped giant unilaminear vesicals (GUVs) reconstituted with cell free expressed PKD2-GFP protein. E ) Top , example WT PKD2-GFP unitary single channel events recorded (HP = 40mV) from GUVs composed of either 1,2-diphytanoyl-sn-glycero-phosphocholine (DPhPC) or 95% DPhPC and 5% cholesterol (Bovine). Bottom , lack of single channel events from D511V channels reconstituted in GUVs. F ) Column plots indicating the frequency of the maximum simultaneous open channel events from GUVs patches. Number of recordings indicated above for each column.

    Article Snippet: Lipids DPhPC (95%) and cholesterol (bovine, 5%) were obtained from Avanti Polar Lipids (Alabaster, USA) and mixed in chloroform, where vacuum evaporation on glass formed small unilaminar vesicles (SUVs), rehydrated and passed through a 100-nm polycarbonate filter with a Mini-Extruder (Avanti Polar Lipids).

    Techniques: Expressing, Membrane